Madrid to Seville drive time, distance, costs & the best stops

The drive from Madrid to Seville covers 331 miles (533 km) and takes about 5 hr 50 min without stops. That's a long day, but doable in one go with a couple of proper breaks. If you'd rather split it, Mérida is about halfway.

Two roads do the work. Roughly 44% is on the A-5R and another 34% on the A-66. On the way you go past Móstoles, Talavera de la Reina and Navalmoral de la Mata, and you'll be near Mérida roughly 3 h 46 min in.

There's real climbing in this one: the road gets up to roughly 668 m near Móstoles, with something like 827 m of ascent over the whole drive.

Expect fuel for a typical petrol car (~40 mpg) to cost around €58 one-way plus roughly €14 in motorway tolls. Prices shift monthly, so treat these as ballpark figures.

At 331 miles this is longer than 83% of the 144 routes covered here, so it is worth treating as a trip in itself rather than a transfer. Split across 2 days it works out at about 2.9 hours behind the wheel each day, which leaves most of the daylight for the places in between.